{
  "provenance": {
    "file": "EnzSub_Source_Data.xlsx",
    "sha256": "8d4c4c6995760a3f5c35de9da6d44507c3ea7d0523dce1761f7a76ea281027f2",
    "sheet": "Fig.3a",
    "extracted_on": "2026-10-14",
    "uncertainty": "mean ± SD where n=3; EC is deterministic, n=1",
    "scope": "Three backbones, four representation states, six task/dataset readouts. Comparison is within the same backbone and readout."
  },
  "rows": [
    {
      "backbone": "ESM2-650M",
      "state": "Base",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.544284957556085,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.34417193142007,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.719844175949236,
      "sd": 0.0069032174698959,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.600854301676113,
      "sd": 0.00141338803466004,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.481331680418713,
      "sd": 0.00311662684645308,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.488618417207302,
      "sd": 0.00245258682926828,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.549636787724939,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.349789234579782,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.737482478705673,
      "sd": 0.00403171389659865,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.60144079656712,
      "sd": 0.00172673876626904,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.493094523901846,
      "sd": 0.0103880721425388,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.497252773267525,
      "sd": 0.00248335112222785,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base-SUB",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.599714040142287,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base-SUB",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.417194812450439,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base-SUB",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.790068129393034,
      "sd": 0.00349628670789336,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base-SUB",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.62925887793919,
      "sd": 0.00224755254877197,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base-SUB",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.330088119986704,
      "sd": 0.0031323874034817,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "Base-SUB",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.481904071095125,
      "sd": 0.0158439261974438,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT-SUB",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.602340712024639,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT-SUB",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.440170197091334,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT-SUB",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.789659626206457,
      "sd": 0.00249391686947479,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT-SUB",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.632719695155359,
      "sd": 0.00391699151497274,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT-SUB",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.315275231713375,
      "sd": 0.00777211252303114,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-650M",
      "state": "CPT-SUB",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.460844655268501,
      "sd": 0.00513996292884414,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.563727020755786,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.431097435472516,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.743756725727903,
      "sd": 0.00873267564765376,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.597561424625952,
      "sd": 0.00407068996643523,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.463810490547525,
      "sd": 0.00378607883669866,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.507702762341886,
      "sd": 0.0082827390382195,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.562232834684693,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.414610833133911,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.748053981185556,
      "sd": 0.0046398082466923,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.616141939566414,
      "sd": 0.00461381490904242,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.486676265105682,
      "sd": 0.00236885173585152,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.525098462209365,
      "sd": 0.00896832251376034,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base-SUB",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.608995241931594,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base-SUB",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.429749056652415,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base-SUB",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.800121553405372,
      "sd": 0.00537654757461146,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base-SUB",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.622526779253721,
      "sd": 0.00141151474284243,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base-SUB",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.308750480059063,
      "sd": 0.00454657658744152,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "Base-SUB",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.504532959583202,
      "sd": 0.00459135755242598,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT-SUB",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.62556118784858,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT-SUB",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.439355637081514,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT-SUB",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.796560726508523,
      "sd": 0.00202188332855524,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT-SUB",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.621977790800848,
      "sd": 0.00184410547079169,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT-SUB",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.31496067435114,
      "sd": 0.0156301408061255,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ESM2-3B",
      "state": "CPT-SUB",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.529291178560515,
      "sd": 0.00804142843897439,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.446269221159438,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.148523252542775,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.583115106241211,
      "sd": 0.00704371213639526,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.536333937462494,
      "sd": 0.00303374022266302,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.454368170975008,
      "sd": 0.00355642153883203,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.356205632440984,
      "sd": 0.00255342054735919,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.420397786466813,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.121671431527779,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.566729080027347,
      "sd": 0.00522572829902797,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.54733342133895,
      "sd": 0.00510042757367488,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.509187212096699,
      "sd": 0.00743749392702391,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.372392000227095,
      "sd": 0.00512794442477949,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base-SUB",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.563343185284225,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base-SUB",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.344449859047028,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base-SUB",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.662558432109911,
      "sd": 0.0071362702747643,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base-SUB",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.596370728226708,
      "sd": 0.00206964242053449,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base-SUB",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.340842083272791,
      "sd": 0.00767874505068427,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "Base-SUB",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.369263062158937,
      "sd": 0.0110448133409094,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT-SUB",
      "task": "EC",
      "dataset": "NEW-392",
      "metric": "MCC",
      "value": 0.572668475757493,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT-SUB",
      "task": "EC",
      "dataset": "PRICE-149",
      "metric": "MCC",
      "value": 0.385598072341871,
      "sd": null,
      "n": 1,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT-SUB",
      "task": "ESP",
      "dataset": "酶–底物特异性",
      "metric": "MCC",
      "value": 0.668231393141594,
      "sd": 0.00847348792845984,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT-SUB",
      "task": "pH",
      "dataset": "最适 pH",
      "metric": "Spearman ρ",
      "value": 0.594611735918497,
      "sd": 0.0019278014814744,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT-SUB",
      "task": "Tm",
      "dataset": "熔解温度",
      "metric": "Spearman ρ",
      "value": 0.360514314899643,
      "sd": 0.0053075472978389,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    },
    {
      "backbone": "ProtBERT-BFD",
      "state": "CPT-SUB",
      "task": "AS",
      "dataset": "活性位点",
      "metric": "MCC",
      "value": 0.377107818447815,
      "sd": 0.00622876885831416,
      "n": 3,
      "higher_is_better": true,
      "source_sheet": "Fig.3a"
    }
  ],
  "routes": [
    {
      "panel": "EC NEW",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ESM2-650M",
      "role": "Base",
      "state": "BASE",
      "mean": "0.5442849575560846",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC NEW",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ESM2-650M",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.6023407120246386",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC NEW",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ESM2-3B",
      "role": "Base",
      "state": "BASE",
      "mean": "0.5637270207557858",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC NEW",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ESM2-3B",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.6255611878485801",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC NEW",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ProtBERT-BFD",
      "role": "Base",
      "state": "BASE",
      "mean": "0.446269221159438",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC NEW",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ProtBERT-BFD",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.5726684757574927",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC PRICE",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ESM2-650M",
      "role": "Base",
      "state": "BASE",
      "mean": "0.3441719314200696",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC PRICE",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ESM2-650M",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.440170197091334",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC PRICE",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ESM2-3B",
      "role": "Base",
      "state": "BASE",
      "mean": "0.4310974354725162",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC PRICE",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ESM2-3B",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.4393556370815143",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC PRICE",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ProtBERT-BFD",
      "role": "Base",
      "state": "BASE",
      "mean": "0.1485232525427752",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "EC PRICE",
      "task": "EC",
      "task_family": "EC retrieval",
      "metric": "MCC",
      "backbone": "ProtBERT-BFD",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.3855980723418705",
      "sd": "",
      "n_replicates": "1",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "ESP",
      "task": "ESP",
      "task_family": "Reaction context",
      "metric": "MCC",
      "backbone": "ESM2-650M",
      "role": "Base",
      "state": "BASE",
      "mean": "0.7198441759492359",
      "sd": "0.006903217469895901",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "ESP",
      "task": "ESP",
      "task_family": "Reaction context",
      "metric": "MCC",
      "backbone": "ESM2-650M",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.7896596262064568",
      "sd": "0.002493916869474786",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "ESP",
      "task": "ESP",
      "task_family": "Reaction context",
      "metric": "MCC",
      "backbone": "ESM2-3B",
      "role": "Base",
      "state": "BASE",
      "mean": "0.7437567257279026",
      "sd": "0.008732675647653758",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "ESP",
      "task": "ESP",
      "task_family": "Reaction context",
      "metric": "MCC",
      "backbone": "ESM2-3B",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.7965607265085234",
      "sd": "0.002021883328555242",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "ESP",
      "task": "ESP",
      "task_family": "Reaction context",
      "metric": "MCC",
      "backbone": "ProtBERT-BFD",
      "role": "Base",
      "state": "BASE",
      "mean": "0.5831151062412112",
      "sd": "0.007043712136395256",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "ESP",
      "task": "ESP",
      "task_family": "Reaction context",
      "metric": "MCC",
      "backbone": "ProtBERT-BFD",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.6682313931415935",
      "sd": "0.008473487928459835",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "pH",
      "task": "pH",
      "task_family": "Reaction context",
      "metric": "Spearman rho",
      "backbone": "ESM2-650M",
      "role": "Base",
      "state": "BASE",
      "mean": "0.6008543016761131",
      "sd": "0.001413388034660038",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "pH",
      "task": "pH",
      "task_family": "Reaction context",
      "metric": "Spearman rho",
      "backbone": "ESM2-650M",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.632719695155359",
      "sd": "0.003916991514972742",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "pH",
      "task": "pH",
      "task_family": "Reaction context",
      "metric": "Spearman rho",
      "backbone": "ESM2-3B",
      "role": "Base",
      "state": "BASE",
      "mean": "0.5975614246259516",
      "sd": "0.004070689966435234",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "pH",
      "task": "pH",
      "task_family": "Reaction context",
      "metric": "Spearman rho",
      "backbone": "ESM2-3B",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.6219777908008478",
      "sd": "0.001844105470791687",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "pH",
      "task": "pH",
      "task_family": "Reaction context",
      "metric": "Spearman rho",
      "backbone": "ProtBERT-BFD",
      "role": "Base",
      "state": "BASE",
      "mean": "0.5363339374624937",
      "sd": "0.003033740222663022",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "pH",
      "task": "pH",
      "task_family": "Reaction context",
      "metric": "Spearman rho",
      "backbone": "ProtBERT-BFD",
      "role": "Routed EnzSub",
      "state": "CPT-SUB",
      "mean": "0.5946117359184974",
      "sd": "0.001927801481474395",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Tm",
      "task": "Tm",
      "task_family": "Sequence / stability",
      "metric": "Spearman rho",
      "backbone": "ESM2-650M",
      "role": "Base",
      "state": "BASE",
      "mean": "0.4813316804187126",
      "sd": "0.003116626846453084",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Tm",
      "task": "Tm",
      "task_family": "Sequence / stability",
      "metric": "Spearman rho",
      "backbone": "ESM2-650M",
      "role": "Routed EnzSub",
      "state": "CPT",
      "mean": "0.493094523901846",
      "sd": "0.01038807214253875",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Tm",
      "task": "Tm",
      "task_family": "Sequence / stability",
      "metric": "Spearman rho",
      "backbone": "ESM2-3B",
      "role": "Base",
      "state": "BASE",
      "mean": "0.4638104905475249",
      "sd": "0.00378607883669866",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Tm",
      "task": "Tm",
      "task_family": "Sequence / stability",
      "metric": "Spearman rho",
      "backbone": "ESM2-3B",
      "role": "Routed EnzSub",
      "state": "CPT",
      "mean": "0.486676265105682",
      "sd": "0.002368851735851515",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Tm",
      "task": "Tm",
      "task_family": "Sequence / stability",
      "metric": "Spearman rho",
      "backbone": "ProtBERT-BFD",
      "role": "Base",
      "state": "BASE",
      "mean": "0.4543681709750076",
      "sd": "0.003556421538832026",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Tm",
      "task": "Tm",
      "task_family": "Sequence / stability",
      "metric": "Spearman rho",
      "backbone": "ProtBERT-BFD",
      "role": "Routed EnzSub",
      "state": "CPT",
      "mean": "0.5091872120966989",
      "sd": "0.007437493927023912",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Active site",
      "task": "Active site",
      "task_family": "Sequence / stability",
      "metric": "MCC",
      "backbone": "ESM2-650M",
      "role": "Base",
      "state": "BASE",
      "mean": "0.4886184172073018",
      "sd": "0.002452586829268277",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Active site",
      "task": "Active site",
      "task_family": "Sequence / stability",
      "metric": "MCC",
      "backbone": "ESM2-650M",
      "role": "Routed EnzSub",
      "state": "CPT",
      "mean": "0.4972527732675254",
      "sd": "0.002483351122227846",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Active site",
      "task": "Active site",
      "task_family": "Sequence / stability",
      "metric": "MCC",
      "backbone": "ESM2-3B",
      "role": "Base",
      "state": "BASE",
      "mean": "0.5077027623418863",
      "sd": "0.008282739038219501",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Active site",
      "task": "Active site",
      "task_family": "Sequence / stability",
      "metric": "MCC",
      "backbone": "ESM2-3B",
      "role": "Routed EnzSub",
      "state": "CPT",
      "mean": "0.5250984622093654",
      "sd": "0.008968322513760339",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Active site",
      "task": "Active site",
      "task_family": "Sequence / stability",
      "metric": "MCC",
      "backbone": "ProtBERT-BFD",
      "role": "Base",
      "state": "BASE",
      "mean": "0.3562056324409835",
      "sd": "0.002553420547359193",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    },
    {
      "panel": "Active site",
      "task": "Active site",
      "task_family": "Sequence / stability",
      "metric": "MCC",
      "backbone": "ProtBERT-BFD",
      "role": "Routed EnzSub",
      "state": "CPT",
      "mean": "0.3723920002270949",
      "sd": "0.005127944424779493",
      "n_replicates": "3",
      "route_fixed_from": "training-side validation"
    }
  ]
}